Professor Darek Gorecki
Biography
Darek Gorecki was born in Warsaw, Poland where he read medicine and obtained his PhD. His key research interest is pathogenesis of Duchenne muscular dystrophy. He started research in this area as a post-doctoral fellow in the Molecular Neurobiology Unit, University of Cambridge under Professor Eric A Barnard, FRS. He continued it at the Royal Free & University College Medical School in London working as a research fellow and later obtained a personal Wellcome Trust Research Career Development Fellowship. After moving to his present laboratory in Portsmouth he has worked as a Senior Lecturer, Reader and, since 2007, Professor of Molecular Medicine. He is the Director of Research in the School of Pharmacy and Biomedical Sciences. In 2011 he won Distinguished Fulbright Scholarship to work at Harvard Medical School, USA researching the role of specific ATP receptors in muscular dystrophy.
For more information about my research please visit my lab page.
Research interests
Pathogenesis and treatment of Duchenne muscular dystrophy, role of the dystrophin complex in the brain, purinoceptors, gene therapy using non-viral vectors.
Research outputs
2024
Investigating the involvement of C−X−C Motif Chemokine 5 and P2X7 purinoceptor in ectopic calcification in mouse models of Duchenne muscular dystrophy
Górecki, D. C., Pomeroy, J., Rumney, R. M. H.
25 Jun 2024, In: Journal of Cellular Biochemistry, 11p., e30617
Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas
Alnassar, N., Banna, G. L., Derry, J. M. J., Gorecki, D. C.
29 Apr 2024, In: Translational Lung Cancer Research. 13, 4, p. 733-748
The P2×7 receptor is a master regulator of microparticle and mitochondria exchange in mouse microglia
Adinolfi, E., Boldrini, P., Chiozzi, P., Di Virgilio, F., Falzoni, S., Giuliani, A. L., Gorecki, D., Morciano, G., Tang, Y., Tarantini, M., Vultaggio-Poma, V.
17 Apr 2024, In: Function
2023
Primary mouse myoblast metabotropic purinoceptor profiles and calcium signalling differ with their muscle origin and are altered in mdx dystrophinopathy
Górecki, D. C., Oksiejuk, A., Róg, J., Zabłocki, K.
1 Dec 2023, In: Scientific Reports. 13, 1, 18p., 9333
The role of P2X7 purinoceptors in the pathogenesis and treatment of muscular dystrophies
Górecki, D. C., Zabłocki, K.
29 May 2023, In: International Journal of Molecular Sciences. 24, 11, 15p., 9434
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies
Gόrecki, D. C., Rumney, R. M. H.
1 Apr 2023, In: Current Opinion in Pharmacology. 69, 8p., 102357
Automated multi-sample DNA extraction for genotyping live Xenopus embryos
Alles, N., Guille, M., Górecki, D. C.
1 Mar 2023, In: Developmental Dynamics. 252, 3, p. 429-438, 10p.
Downregulation of dystrophin expression occurs across diverse tumors, correlates with the age of onset, staging and reduced survival of patients
Alnassar, N., Borczyk, M., Górecki, D. C., Han, N., Korostynski, M., Tsagkogeorga, G.
21 Feb 2023, In: Cancers. 15, 5, 28p., 1378