Summary
Dr Farah El Mohtadi has completed her PhD in Pharmacy and Pharmaceutical Sciences from The University of Manchester Division of Pharmacy and Optometry. Her PhD research project focused on developing novel nanomaterials for combinatory therapeutic and diagnostic purposes. Following which, she was appointed as postdoctoral research associate at The University of Manchester Division of Pharmacy and Optometry focusing on the molecular design and application of oxidation responsive polymer-based technologies for intracellular delivery of biological drugs such as enzymes. She recently joined the University of Portsmouth School of Pharmacy and Biomedical Sciences as Senior Lecturer in Pharmaceutical Sciences. Her research focuses on developing smart vectors for delivering a broad range of therapeutic agents, and fabricating multifunctional nanoparticles to target cancer and other diseases. Her long-term research career is to facilitate the translation of nanoparticle-based therapeutics from the lab to the clinic.
Research interests
Her research expertise is in developing novel polymeric materials with functions inspired by biological systems. These materials generate platforms of new biomimetic polymeric architectures addressing growing concerns in treating, diagnosing, and preventing chronic diseases (cancer disease, cardiovascular diseases, and lysosomal storage diseases). Throughout her career, she has studied a number of biomaterials including polymeric, emulsion and micellar based systems in a number of models where the ultimate application steers the choice of material. Her research interest is centered on the molecular design and application of stimuli responsive polymer-based technologies for cancer therapy. These delivery systems are designed to improve the therapeutic benefit and safety of existing drugs, proteins and/or to serve as enabling technologies for manipulation of intracellular targets currently considered “undruggable”.
Research outputs
2023
Dual thermal- and oxidation-responsive polymers synthesized by a sequential ROP-to-RAFT procedure inherently temper neuroinflammation
Alshamsan, A., Benefanti, F., Castagnola, V., El Mohtadi, F., Francini, N., Geven, M., Teixeira, L. I., Tirelli , N., Turhan, Z. Y., d’Arcy, R.
9 Oct 2023, In: Biomacromolecules. 24, 10, p. 4329-4510, 16p.
Polysulfide nanoparticles inhibit fibroblast-to-myofibroblast transition via extracellular ROS scavenging and have potential anti-fibrotic properties
Donno, R., D’Arcy, R., El Mohtadi, F., Roberts, I. V., Siani, A., Teixeira, L. I., Tirelli, N.
1 Oct 2023, In: Biomaterials Advances. 153, 13p., 213537