Dr Murphy Wan
Biography
Dr Murphy Wan is a Senior Lecturer in Biomedical Sciences within the School of Pharmacy and Biomedical Sciences at University of Portsmouth.
Her current research focuses largely on discovery of novel therapies for infectious diseases or cancer, through understanding of the complex interplay between diet/pathogens, immune system as well as gut microbiome. Her projects involve integration of different molecular approaches and omics technologies for in-depth investigation of disease mechanisms and discoveries of novel biomarkers that can be translated in future clinical settings.
Her current research projects include:
- development of colon-targeted delivery approach for colon cancer
- exploring the potential of natural compounds as novel cancer therapeutics
- investigating the immunological potential of molecules excreted from bacteria and their potential therapeutic effects in human diseases
More information can be found at https://www.mwanlab.com/
Dr Murphy Wan welcomes MRes and PhD students. Please email murphy.wan@port.ac.uk to discuss further.
Research interests
1. Discovery and development of novel therapies against infection, inflammatory diseases and cancer;
2. Exploring how the microbiota affect host immunity to diseases;
3. Emphasis on integration of different omics technologies for in-depth investigation of disease mechanisms and discoveries of novel biomarkers.
Research outputs
2024
Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
Co, V. A., El-Nezami, H., Lee, P., Wan, M. L. Y., Yang, Y., Zhao, D.
26 Sep 2024, In: Food Chemistry. 463, 9p., 141371
Schisandrin B suppresses colon cancer growth by inducing cell cycle arrest and apoptosis: molecular mechanism and therapeutic potential
Agbodjan-Dossou, R., Co, V. A., Cox, P. A., Dey, P., Draheim, R., El-Nezami, H., Joseph, S., Liu, Y., Sabzichi, M., Twum, B., Wan, M. L. Y.
8 Mar 2024, In: ACS Pharmacology & Translational Science. 7, 3, p. 863-877
BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health
Ahmadi, S., Ambite, I., Carneiro, A. N. B. M., Cavalera, M., Chaudhuri, A., Esmaeili, P., Grossi, M., Háček, J., Svanborg, C., Tran, T. H., Wan, M.
15 Feb 2024, In: Scientific Reports. 14, 21p., 3838
2023
Therapeutic effects of IL-1RA against acute bacterial infections, including antibiotic-resistant strains
Ahmadi, S., Ambite, I., Butler, D., Cavalera, M., Svanborg, C., Tran, T. H., Wan, M.
31 Dec 2023, In: Pathogens. 13, 1, 18p., 42
Long-term prevention of bladder cancer progression by alpha1-oleate alone or in combination with chemotherapy
Ambite, I., Babjuk, M., Cavalera, M., Chaudhuri, A., Esmaeili, P., Hien, T. T., Sabari, S., Svanborg, C., Wan, M.
1 Aug 2023, In: International Journal of Cancer. 153, 3, p. 584-599
Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis
Chavoshi, H., Sabzichi, M., Taheri, M., Wan, M. L. Y.
1 Jul 2023, In: Process Biochemistry. 130, 9p.